Cancer

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Cancer is the most pressing health challenge of our time. By the age of 85, cancer will affect 1 in 2 Australians. While health and medical research has improved the outlook for cancer patients in recent decades, cancer is still a leading cause of death worldwide. Our researchers are investigating multiple aspects of cancer biology to identify the mechanisms that drive disease progression, to understand the role of the immune system in patient outcomes and to identify novel treatment mechanisms. This work harnesses local strengths in cutting edge imaging and personalised medicine.��

Research groups

Curious how cells are kept running like well-oiled machines, Vaishnavi Ananthanarayanan uses high resolution, live cell imaging to investigate cellular dynamics within the crowded environment inside mammalian cells.��

The Biro Group investigates how immune cells locate and kill cancer cells, adopting multi-disciplinary methods encompassing biophysics, cell biology, immunology, cancer biology, advanced microscopy, image analysis, and mathematical and coputational modelling.

The Davis Lab explores how intracellular calcium signalling orchestrates the development, function and regeneration of the mammary gland. Our research utilizes genetic model organisms and quantitative imaging (across the scales of cells, tissues and the organ as a whole).

Faridani Group: Single Cell Technologies and Precision Oncology

The Faridani lab uses state-of-the-art technology in the field of "single cell omics" to tackle hard-to-crack problems of cancer treatment, with a focus on pancreatic cancer and other solid tumours. The main goal of the lab is to tailor treatment for each patient.

Hardeman & Gunning Group: Cytoskeleton Therapeutics Research Unit (CTRU)

The CTRU studies the building blocks of cell architecture and develops therapeutic strategies based on drug-targeting these building blocks. Our focus is the actin cytoskeleton that is responsible for the internal scaffolds of cells, the generation and reaction to force exerted by the environment and the movement of cells throughout the body.��

Holst Group: Translational Cancer Metabolism Laboratory

Our laboratory utilises a variety of in vitro, ex vivo and in vivo techniques to dissect out the role of key transporters and metabolic enzymes in cancer growth. We have determined a number of metabolic pathways that are differentially regulated in breast cancer, prostate cancer, melanoma and more recently glioblastoma.

Khachigian Group: Vascular Biology and Translational Research

The Khachigian Group has 2 principal aims:

To better understand how potentially harmful genes are controlled in vascular cells.��
To develop novel vascular therapeutic agents for cardiovascular and inflammatory disease, tumour growth and metastasis.��

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Cancer

Research groups