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Dr Iman Roohani

Dr Iman Roohani

Visiting Fellow

(B.Sc. Mater Sci, M.Sc. Biomat Sci, Ph.D. Biomed Eng),

Engineering
School of Chemical Engineering

Biographical Details

I was awarded my Ph.D. degree in 2014 (in Biomedical Engineering, Biomaterials and Tissue Engineering) from University of Sydney. My research group is investigating cell-biomaterial based strategies for musculoskeletal tissue regeneration and their application in the clinical translation of orthopaedic medical devices. This research technology platform involves 3D Biofabrication and additive manufacturing of biomaterials and medical devices applied to regenerative medicine of bone and development of novel nanocarriers and bone grafts to promote bone healing or treat bone diseases. Throughout my career, I have developed several novel biomaterials for the treatment of large bone defects, osteochondral defect regeneration and for stabilisation of metallic implants. I was fortunate as an early career researcher and the main inventor, to translate an innovative bioengineering technology from the laboratory bench through to successful commercialisation of a tissue engineering product. This product, a novel synthetic bone graft, Sr-HT-Gahnite, has been exclusively licenced globally by an Australian orthopaedic medical device company, Allegra Orthopaedics. Allegra was awarded $1.6M from the NSW Government Medical Devices Fund in 2015 to bring this technology to market. My achievements have been recognised through receiving of the Australian National Health and Medical Research Council (NHMRC) Early Career Fellowship for funding in 2016–2019.In 2017, I moved to University of New South Wales, School of Chemistry as a research fellow to work closely with Scientia Professor Justin Gooding and establish a Biomaterials Design and Tissue Engineering lab.

Available projects

  • Cell-instructive and cell-responsive biomaterials (the aim is to develop a unique approach in building biomaterials that are cell-instructive and cell-responsive. This can create a selective and dynamic feedback loop between a cell and the microenvironment).
  • Gene activating scaffolds (The aim of this study is to develop a new generation of 3D constructs that can host cells in a 3D dimensional environment and are able to deliver biomolecules into the cells).
  • New generation of bioceramic, bioactive glasses and bone cements for musculoskeletal tissue regeneration.
  • Development of universal methodologies to test efficacy of biomaterials; replacing the conventional methods.
  • Printing complexed shaped inorganic based tissue scaffolds for tissue engineering applications.
  • Synthesis of new generation of bioceramic, bioactive glasses and bone cements for musculoskeletal tissue regeneration.
  • Development of biomaterials as synthetic tendon, skin and treatment of cardiovascular disease.
  • Biomaterials for neural regeneration (material effects on cell behaviours such as proliferation, differentiation, directed neurite growth, and tissue function).
  • An exhaustive investigation on Biomaterials-microstructure-protein/cell interactions.
  • Surface coating strategies for medical implants and tissue scaffolds.
  • Designing load bearing scaffolds for treatment of segmental bone defects.
  • Synthesis and fabrication of multifunctional calcium phosphate nanoparticles.

Interested in joining the group?

Please contact me

  • Book Chapters | 2021
    Romanazzo S; Kilian KA; Roohani I, 2021, 'iPSC bioprinting for musculoskeletal tissue', in Ipscs in Tissue Engineering, pp. 237 - 270,
    Book Chapters | 2012
    Roohani-Esfahani SI; Zreiqat HH, 2012, 'Ceramic Scaffolds, Current Issues and Future Trends', in Integrated Biomaterials in Tissue Engineering, pp. 25 - 46,
  • Journal articles | 2023
    Chakraborty S; Katsifis G; Roohani I; Boyer C; McKenzie D; Willcox MDP; Chen R; Kumar N, 2023, 'Electrostatic and Covalent Binding of an Antibacterial Polymer to Hydroxyapatite for Protection against Escherichia coli Colonization', Materials, 16, pp. 5045,
    Journal articles | 2023
    Holmes NP; Roohani I; Entezari A; Guagliardo P; Mirkhalaf M; Lu Z; Chen YS; Yang L; Dunstan CR; Zreiqat H; Cairney JM, 2023, 'Discovering an unknown territory using atom probe tomography: Elemental exchange at the bioceramic scaffold/bone tissue interface', Acta Biomaterialia, 162, pp. 199 - 210,
    Journal articles | 2023
    Hume RD; Kanagalingam S; Deshmukh T; Chen S; Mithieux SM; Rashid FN; Roohani I; Lu J; Doan T; Graham D; Clayton ZE; Slaughter E; Kizana E; Stempien-Otero AS; Brown P; Thomas L; Weiss AS; Chong JJH, 2023, 'Tropoelastin Improves Post-Infarct Cardiac Function', Circulation Research, 132, pp. 72 - 86,
    Journal articles | 2023
    Jalandhra GK; Molley TG; Hung TT; Roohani I; Kilian KA, 2023, 'In situ formation of osteochondral interfaces through “bone-ink” printing in tailored microgel suspensions', Acta Biomaterialia, 156, pp. 75 - 87,
    Journal articles | 2023
    Roohani I; Newsom E; Zreiqat H, 2023, 'High-resolution vat-photopolymerization of personalized bioceramic implants: new advances, regulatory hurdles, and key recommendations', International Materials Reviews, 68, pp. 1075 - 1097,
    Journal articles | 2023
    Sabahi N; Roohani I; Wang CH; Farajzadeh E; Li X, 2023, 'Thermoplastic polyurethane-based shape memory polymers with potential biomedical application: The effect of TPU soft-segment on shape memory effect and cytocompatibility', Polymer, 283,
    Journal articles | 2022
    Jalandhra G; Romanazzo S; Nemec S; Roohani I; Kilian KA, 2022, 'Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs', Journal of Visualized Experiments,
    Journal articles | 2022
    Jalandhra G; Romanazzo S; Nemec S; Roohani I; Kilian KA, 2022, 'Ceramic Omnidirectional Bioprinting in Cell-laden Suspensions for the Generation of Bone Analogs', Journal of Visualized Experiments, 2022,
    Journal articles | 2022
    Roohani I; No YJ; Zuo B; Xiang SD; Lu Z; Liu H; Plebanski M; Zreiqat H, 2022, 'Low-Temperature Synthesis of Hollow β‑Tricalcium Phosphate Particles for Bone Tissue Engineering Applications', ACS Biomaterials Science and Engineering, 8, pp. 1806 - 1815,
    Journal articles | 2022
    Roohani I; Yeo GC; Mithieux SM; Weiss AS, 2022, 'Emerging concepts in bone repair and the premise of soft materials', Current Opinion in Biotechnology, 74, pp. 220 - 229,
    Journal articles | 2021
    Chakraborty S; Kuppusamy R; Roohani I; Walsh WR; Willcox MDP; Kumar N; Chen R, 2021, 'Antibacterial peptidomimetic and characterization of its efficacy as an antibacterial and biocompatible coating for bioceramic-based bone substitutes', Materials Advances, 2, pp. 6369 - 6379,
    Journal articles | 2021
    Ramaswamy Y; Roohani I; No YJ; Madafiglio G; Chang F; Zhang F; Lu Z; Zreiqat H, 2021, 'Nature-inspired topographies on hydroxyapatite surfaces regulate stem cells behaviour', Bioactive Materials, 6, pp. 1107 - 1117,
    Journal articles | 2021
    Romanazzo S; Molley TG; Nemec S; Lin K; Sheikh R; Gooding JJ; Wan B; Li Q; Kilian KA; Roohani I, 2021, 'Synthetic Bone-Like Structures Through Omnidirectional Ceramic Bioprinting in Cell Suspensions', Advanced Functional Materials, 31, pp. 2008216,
    Journal articles | 2021
    Roohani I; Cheong S; Wang A, 2021, 'How to build a bone? - Hydroxyapatite or Posner's clusters as bone minerals', Open Ceramics, 6,
    Journal articles | 2020
    Entezari A; Liu NC; Roohani I; Zhang Z; Chen J; Sarrafpour B; Zoellner H; Behi M; Zreiqat H; Li Q, 2020, 'On design for additive manufacturing (DAM) parameter and its effects on biomechanical properties of 3D printed ceramic scaffolds', Materials Today Communications, 23,
    Journal articles | 2020
    Entezari A; Swain MV; Gooding JJ; Roohani I; Li Q, 2020, 'A modular design strategy to integrate mechanotransduction concepts in scaffold-based bone tissue engineering', Acta Biomaterialia, 118, pp. 100 - 112,
    Journal articles | 2020
    Lin X; Romanazzo S; Lin K; Kelly C; Gooding JJ; Roohani I, 2020, 'Elliptical supra-cellular topographies regulate stem cells migratory pattern and osteogenic differentiation', Materialia, 14, pp. 100870,
    Journal articles | 2019
    Entezari A; Roohani I; Li G; Dunstan CR; Rognon P; Li Q; Jiang X; Zreiqat H, 2019, 'Architectural Design of 3D Printed Scaffolds Controls the Volume and Functionality of Newly Formed Bone', Advanced Healthcare Materials, 8,
    Journal articles | 2019
    Jia Z; Xiu P; Roohani-Esfahani SI; Zreiqat H; Xiong P; Zhou W; Yan J; Cheng Y; Zheng Y, 2019, 'Triple-Bioinspired Burying/Crosslinking Interfacial Coassembly Strategy for Layer-by-Layer Construction of Robust Functional Bioceramic Self-Coatings for Osteointegration Applications', ACS Applied Materials and Interfaces, 11, pp. 4447 - 4469,
    Journal articles | 2019
    Li JJ; Dunstan CR; Entezari A; Li Q; Steck R; Saifzadeh S; Sadeghpour A; Field JR; Akey A; Vielreicher M; Friedrich O; Roohani-Esfahani SI; Zreiqat H, 2019, 'A Novel Bone Substitute with High Bioactivity, Strength, and Porosity for Repairing Large and Load-Bearing Bone Defects', Advanced Healthcare Materials, 8,
    Journal articles | 2019
    Li JJ; Dunstan CR; Entezari A; Li Q; Steck R; Saifzadeh S; Sadeghpour A; Field JR; Akey A; Vielreicher M; Friedrich O; Roohani-Esfahani SI; Zreiqat H, 2019, 'Correction to: A Novel Bone Substitute with High Bioactivity, Strength, and Porosity for Repairing Large and Load-Bearing Bone Defects (Advanced Healthcare Materials, (2019), 8, 8, (1801298), 10.1002/adhm.201801298)', Advanced Healthcare Materials, 8,
    Journal articles | 2019
    Lin K; Sheikh R; Romanazzo S; Roohani I, 2019, '3D printing of bioceramic scaffolds-barriers to the clinical translation: From promise to reality, and future perspectives', Materials, 12,
    Journal articles | 2019
    Romanazzo S; Nemec S; Roohani I, 2019, 'iPSC bioprinting: Where are we at?', Materials, 12,
    Journal articles | 2019
    Roohaniesfahani I; Wang J; No YJ; de Candia C; Miao X; Lu Z; Shi J; Kaplan DL; Jiang X; Zreiqat H, 2019, 'Modulatory effect of simultaneously released magnesium, strontium, and silicon ions on injectable silk hydrogels for bone regeneration', Materials Science and Engineering C, 94, pp. 976 - 987,
    Journal articles | 2017
    Li JJ; Roohani-Esfahani SI; Kim K; Kaplan DL; Zreiqat H, 2017, 'Silk coating on a bioactive ceramic scaffold for bone regeneration: effective enhancement of mechanical and in vitro osteogenic properties towards load-bearing applications', Journal of Tissue Engineering and Regenerative Medicine, 11, pp. 1741 - 1753,
    Journal articles | 2017
    Lu Z; Chen Y; Dunstan C; Roohani-Esfahani S; Zreiqat H, 2017, 'Priming Adipose Stem Cells with Tumor Necrosis Factor-Alpha Preconditioning Potentiates Their Exosome Efficacy for Bone Regeneration', Tissue Engineering Part A, 23, pp. 1212 - 1220,
    Journal articles | 2017
    Roohani-Esfahani SI; Lin K; Zreiqat H, 2017, 'Fabrication of bioinspired structured glass–ceramics with enhanced fracture toughness', Journal of Materials Science, 52, pp. 9202 - 9210,
    Journal articles | 2017
    Roohani-Esfahani SI; Zreiqat H, 2017, 'Nanoparticles: A promising new therapeutic platform for bone regeneration?', Nanomedicine, 12, pp. 419 - 422,
    Journal articles | 2017
    Sehgal RR; Roohani-Esfahani SI; Zreiqat H; Banerjee R, 2017, 'Nanostructured gellan and xanthan hydrogel depot integrated within a baghdadite scaffold augments bone regeneration', Journal of Tissue Engineering and Regenerative Medicine, 11, pp. 1195 - 1211,
    Journal articles | 2017
    Wang G; Roohani-Esfahani SI; Zhang W; Lv K; Yang G; Ding X; Zou D; Cui D; Zreiqat H; Jiang X, 2017, 'Effects of Sr-HT-Gahnite on osteogenesis and angiogenesis by adipose derived stem cells for critical-sized calvarial defect repair', Scientific Reports, 7,
    Journal articles | 2016
    Entezari A; Roohani-Esfahani SI; Zhang Z; Zreiqat H; Dunstan CR; Li Q, 2016, 'Fracture behaviors of ceramic tissue scaffolds for load bearing applications', Scientific Reports, 6,
    Journal articles | 2016
    Graney PL; Roohani-Esfahani SI; Zreiqat H; Spiller KL, 2016, 'In vitro response of macrophages to ceramic scaffolds used for bone regeneration', Journal of the Royal Society Interface, 13,
    Journal articles | 2016
    Li JJ; Roohani-Esfahani SI; Dunstan CR; Quach T; Steck R; Saifzadeh S; Pivonka P; Zreiqat H, 2016, 'Efficacy of novel synthetic bone substitutes in the reconstruction of large segmental bone defects in sheep tibiae', Biomedical Materials Bristol, 11,
    Journal articles | 2016
    Roohani-Esfahani SI; Newman P; Zreiqat H, 2016, 'Design and Fabrication of 3D printed Scaffolds with a Mechanical Strength Comparable to Cortical Bone to Repair Large Bone Defects', Scientific Reports, 6,
    Journal articles | 2016
    Roohani-Esfahani SI; No YJ; Lu Z; Ng PY; Chen Y; Shi J; Pavlos NJ; Zreiqat H, 2016, 'A bioceramic with enhanced osteogenic properties to regulate the function of osteoblastic and osteocalastic cells for bone tissue regeneration', Biomedical Materials Bristol, 11,
    Journal articles | 2015
    Chen Y; Roohani-Esfahani SI; Lu ZF; Zreiqat H; Dunstan CR, 2015, 'Zirconium ions up-regulate the BMP/SMAD signaling pathway and promote the proliferation and differentiation of human osteoblasts', Plos One, 10,
    Journal articles | 2015
    Kariem H; Pastrama MI; Roohani-Esfahani SI; Pivonka P; Zreiqat H; Hellmich C, 2015, 'Micro-poro-elasticity of baghdadite-based bone tissue engineering scaffolds: A unifying approach based on ultrasonics, nanoindentation, and homogenization theory', Materials Science and Engineering C, 46, pp. 553 - 564,
    Journal articles | 2015
    Li JJ; Kim K; Roohani-Esfahani SI; Guo J; Kaplan DL; Zreiqat H, 2015, 'A biphasic scaffold based on silk and bioactive ceramic with stratified properties for osteochondral tissue regeneration', Journal of Materials Chemistry B, 3, pp. 5361 - 5376,
    Journal articles | 2015
    Lu ZF; Roohani-Esfahani SI; Li JJ; Zreiqat H, 2015, 'Synergistic effect of nanomaterials and BMP-2 signalling in inducing osteogenic differentiation of adipose tissue-derived mesenchymal stem cells', Nanomedicine Nanotechnology Biology and Medicine, 11, pp. 219 - 228,
    Journal articles | 2015
    Newman P; Lu Z; Roohani-Esfahani SI; Church TL; Biro M; Davies B; King A; Mackenzie K; Minett AI; Zreiqat H, 2015, 'Porous and strong three-dimensional carbon nanotube coated ceramic scaffolds for tissue engineering', Journal of Materials Chemistry B, 3, pp. 8337 - 8347,
    Journal articles | 2015
    No YJ; Roohani-Esfahani SI; Lu Z; Schaer T; Zreiqat H, 2015, 'Injectable radiopaque and bioactive polycaprolactone-ceramic composites for orthopedic augmentation', Journal of Biomedical Materials Research Part B Applied Biomaterials, 103, pp. 1465 - 1477,
    Journal articles | 2014
    Lu Z; Roohani-Esfahani SI; Zreiqat H, 2014, 'Mimicking bone microenvironment for directing adipose tissue-derived mesenchymal stem cells into osteogenic differentiation', Methods in Molecular Biology, 1202, pp. 161 - 171,
    Journal articles | 2014
    Lu ZF; Roohani-Esfahani SI; Zreiqat H, 2014, 'Mimicking bone microenvironment for directing adipose tissue-derived mesenchymal stem cells into osteogenic differentiation', Methods in molecular biology (Clifton, N.J.), 1202, pp. 161 - 171,
    Journal articles | 2014
    Lu ZF; Wang GC; Roohani-Esfahani I; Dunstan CR; Zreiqat H, 2014, 'Baghdadite ceramics modulate the cross talk between human adipose stem cells and osteoblasts for bone regeneration', Tissue Engineering Part A, 20, pp. 992 - 1002,
    Journal articles | 2014
    Newman P; Roohani-Esfahani SI; Zreiqat H; Minett A, 2014, 'See the extracellular forest for the nanotrees', Materials Today, 17, pp. 43 - 44,
    Journal articles | 2014
    No YJ; Roohani-Esfahani SI; Zreiqat H, 2014, 'Nanomaterials: The next step in injectable bone cements', Nanomedicine, 9, pp. 1745 - 1764,
    Journal articles | 2014
    Roohani-Esfahani SI; Wong KY; Lu Z; Juan Chen Y; Li JJ; Gronthos S; Menicanin D; Shi J; Dunstan C; Zreiqat H, 2014, 'Fabrication of a novel triphasic and bioactive ceramic and evaluation of its in vitro and in vivo cytocompatibility and osteogenesis', Journal of Materials Chemistry B, 2, pp. 1866 - 1878,
    Journal articles | 2013
    Li JJ; Gil ES; Hayden RS; Li C; Roohani-Esfahani SI; Kaplan DL; Zreiqat H, 2013, 'Multiple silk coatings on biphasic calcium phosphate scaffolds: Effect on physical and mechanical properties and in vitro osteogenic response of human mesenchymal stem cells', Biomacromolecules, 14, pp. 2179 - 2188,
    Journal articles | 2013
    Roohani-Esfahani SI; Chen Y; Shi J; Zreiqat H, 2013, 'Fabrication and characterization of a new, strong and bioactive ceramic scaffold for bone regeneration', Materials Letters, 107, pp. 378 - 381,